Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

被引：49

作者：

Deraeve, Celine

Pitie, Marguerite

Mazarguil, Honore

Meunier, Bernard

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

[2] CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France

来源：

NEW JOURNAL OF CHEMISTRY | 2007年 / 31卷 / 02期

关键词：

A-BETA; TRANSGENIC MICE; DISEASE; CLIOQUINOL; CHELATION; COMPLEXES; TOXICITY; BINDING; IONS; H2O2;

D O I：

10.1039/b616085a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy based on the use of a tetradentate ligand containing two linked 8-hydroxyquinolines allowed a significant increase in the ability to protect against beta-amyloid peptide precipitation in the presence of Cu(II), Zn(II) and Fe(III) when compared to clioquinol, a 8-hydroxyquinoline derivative active in vivo.

引用

收藏

页码：193 / 195

页数：3

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