In vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine among schoolchildren in rural Uganda:: a comparison between 1995 and 1998

被引：6

作者：

Ndyomugyenyi, R

Magnussen, P

机构：

[1] Danish Bilharziasis Lab, DK-2920 Charlottenlund, Denmark

[2] Vector Control Div, Kampala, Uganda

来源：

ACTA TROPICA | 2000年 / 76卷 / 03期

关键词：

Plasmodium falciparum; drug resistance; chloroquine; sulfadoxine-pyrimethamine; Uganda;

D O I：

10.1016/S0001-706X(00)00113-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine was tested among asymptomatic school children in 1995 and 1998 using a modified in vivo test with examination for parasitaemia on day 0, 2 and 7. Sensitivity (S/RI) to chloroquine in 'urban' areas was found in 42% in 1995 and 62% in 1998 with resistance at the RII/RIII level observed in 58 and 38%, respectively (P < 0.01). In 'rural' areas, sensitivity to chloroquine was 76% in 1995 and 72% in 1998 (P = 0.6) with resistance at the RII/RIII level observed in 24 and 18%, respectively (P = 0.4). Sensitivity to sulfadoxine-pyrimethamine was found in 98 and 99% in 1995 and 1998, respectively. The apparent improvement in sensitivity to chloroquine in 'urban' areas might be due to a different school being included in the two studies. It is concluded that the pattern of sensitivity of P. falciparum to chloroquine and sulfadoxine-pyrimethamine has not changed over a period of 2.5 year. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：265 / 270

页数：6

共 9 条

[1]

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[2]

BRABIN BJ, 1990, ANN TROP MED PARASIT, V84, P1

[3]

KAMUGISHA J, 1994, TROP GEOGR MED, V46, P364

[4] In vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine in school children in Hoima district, Western Uganda [J].