High-mobility group protein 1(Y): Metastasis-associated or metastasis-inducing?

被引：48

作者：

Evans, A ^{[1
]}

Lennard, TWJ

Davies, BR

机构：

[1] Univ Newcastle Upon Tyne, Sch Surg & Reprod Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Univ Newcastle Upon Tyne, No Inst Canc Res, Fac Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2004年 / 88卷 / 02期

关键词：

HMG-1(Y); metastasis; tumorigenesis;

D O I：

10.1002/jso.20136

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y)[HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis. J. Surg. Oncol. 2004;88:86-99. (C) 2004 Wiley-Liss, Inc.

引用

页码：86 / 99

页数：14

共 59 条

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[2]

Abe N, 2000, CANCER RES, V60, P3117

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