Atherosclerosis of cerebral arteries in Alzheimer disease

被引：124

作者：

Roher, AE

Esh, C

Rahman, A

Kokjohn, TA

Beach, TG

机构：

[1] Sun Hlth Res Inst, Longtine Ctr Mol Biol & Genet, Sun City, AZ 85351 USA

[2] Sun Hlth Res Inst, W Harold Civin Lab Neuropathol, Sun City, AZ 85351 USA

[3] Midwestern Univ, Dept Microbiol, Glendale, AZ USA

来源：

STROKE | 2004年 / 35卷 / 11期

关键词：

Alzheimer disease; atherosclerosis; cerebral ischemia; circle of Willis;

D O I：

10.1161/01.STR.0000143317.70478.b3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A growing body of evidence suggests that vascular disease underlies Alzheimer dementia. Atherosclerotic lesions in the circle of Willis and large leptomeningeal vessels were quantified and found to correlate with Alzheimer disease (AD) clinical diagnosis and neuropathology. We hypothesize that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions. Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia.

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收藏

页码：2623 / 2627

页数：5

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