The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3):: a novel translocation involving the FGFR1 gene

被引：26

作者：

Mugneret, F

Chaffanet, M

Maynadié, M

Guasch, G

Favre, B

Casasnovas, O

Birnbaum, D

Pébusque, MJ

机构：

[1] INSERM, U119, F-13009 Marseille, France

[2] Hop Bocage, Hematol Clin, Lab Cytogenet, Dijon, France

[3] Hop Bocage, Hematol Clin, Hematol Lab, Dijon, France

[4] Inst J Paoli I Calmettes, Lab Biol Tumeurs, F-13009 Marseille, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 111卷 / 02期

关键词：

myeloproliferative disorder; translocation; FGFR1; gene; chromosome; 8; 19;

D O I：

10.1046/j.1365-2141.2000.02355.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.

引用

收藏

页码：647 / 649

页数：3

相关论文

共 7 条

[1] t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12 [J].

Chaffanet, M ;

Popovici, C ;

Leroux, D ;

Jacrot, M ;

Adélaïde, J ;

Dastugue, N ;

Grégoire, MJ ;

Hagemeijer, A ;

Lafage-Pochitaloff, M ;

Birnbaum, D ;

Pébusque, MJ .

ONCOGENE, 1998, 16 (07) :945-949

[2] FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33) [J].

Guasch, G ;

Mack, GJ ;

Popovici, C ;

Dastugue, N ;

Birnbaum, D ;

Rattner, JB ;

Pébusque, MJ .

BLOOD, 2000, 95 (05) :1788-1796

[3] Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation [J].

Ollendorff, V ;

Guasch, G ;

Isnardon, D ;

Galindo, R ;

Birnbaum, D ;

Pébusque, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (38) :26922-26930

[4] The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1 [J].

Popovici, C ;

Zhang, B ;

Grégoire, MJ ;

Jonveaux, P ;

Lafage-Pochitaloff, M ;

Birnbaum, D ;

Pébusque, MJ .

BLOOD, 1999, 93 (04) :1381-1389

[5] Fibroblast growth factor receptor 1 is used to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12) [J].

Popovici, C ;

Adélaïde, J ;

Ollendorff, V ;

Chaffanet, M ;

Guasch, G ;

Jacrot, M ;

Leroux, D ;

Birnbaum, D ;

Pébusque, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (10) :5712-5717

[6]

Sohal J, 1999, BLOOD, V94, p180B

[7] FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome [J].

Xiao, S ;

Nalabolu, SR ;

Aster, JC ;

Ma, JL ;

Abruzzo, L ;

Jaffe, ES ;

Stone, R ;

Weissman, SM ;

Hudson, TJ ;

Fletcher, JA .

NATURE GENETICS, 1998, 18 (01) :84-87