The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

被引：9

作者：

Divers, Jasmin ^{[1
,2
]}

Sale, Michele M. ^{[3
,4
,5
]}

Lu, Lingyi ^{[1
]}

Chen, Wei-Min ^{[3
,6
]}

Lok, Kerry H. ^{[7
]}

Spruill, Ida J. ^{[8
]}

Fernandes, Jyotika K. ^{[8
]}

Langefeld, Carl D. ^{[1
,2
]}

Garvey, W. Timothy ^{[7
,9
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC 27106 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC USA

[3] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

[4] Univ Virginia, Dept Med, Charlottesville, VA USA

[5] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA

[6] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[7] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA

[8] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA

[9] Birmingham VA Med Ctr, Birmingham, AL USA

来源：

JOURNAL OF LIPID RESEARCH | 2010年 / 51卷 / 03期

基金：

美国国家卫生研究院;

关键词：

linkage analysis; lipids; lipoproteins; heritability; genetic correlation; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; TRAIT LINKAGE ANALYSIS; MAGNETIC-RESONANCE-SPECTROSCOPY; ISCHEMIC-HEART-DISEASE; CARDIOVASCULAR-DISEASE; PARTICLE-SIZE; INSULIN-RESISTANCE; HDL CHOLESTEROL; MITOCHONDRIAL-DNA;

D O I：

10.1194/jlr.M001842

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We sought to partition the genetic and environmental influences on lipoprotein subclasses and identify genomic regions that may harbor genetic variants that influence serum lipoprotein levels in a sample of Gullah-speaking African-Americans. We genotyped 5,974 SNPs in 979 subjects from 418 pedigrees and used the variance component approach to compute heritability estimates, genetic and environmental correlations, and linkage analyses for selected lipoprotein subclasses. The highest heritability estimate was observed for large VLDL particle concentration (0.56 +/- 0.14). Mean LDL particle size and small LDL particle concentration (-0.94) had the strongest genetic correlation estimate. The highest logarithm of odds (LOD) score detected (3.0) was on chromosome 6p24 for small LDL particle concentration. The strongest signal, obtained with the reduced sample of diabetic individuals only, was observed on chromosome 20p13 for small LDL particle concentration. The highest bivariate linkage signal (LOD 2.4) was observed on chromosome 6p24 for mean LDL particle size and small LDL particle concentration.jlr Our results suggest a significant genetic contribution to multiple lipoprotein subclasses studied in this sample and that novel loci on chromosomes 6, 10, 16, and 20 may harbor genes contributing to small, atherogenic LDL particle concentration and large, triglyceride-rich VLDL particle concentration.-Divers, J., M. M. Sale, L. Lu, W-M. Chen, K. H. Lok, I. J. Spruill, J. K. Fernandes, C. D. Langefeld, and W. T. Garvey. The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: The Sea Islands Genetic African American Registry (Project SuGAR). J. Lipid Res. 2010. 51: 586-597.

引用

页码：586 / 597

页数：12

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