Recurrent EML4-ALK-associated lung adenocarcinoma with a slow clinical course

被引：11

作者：

Murakami, Shuji ^{[1
]}

Yokose, Tomoyuki ^{[2
]}

Saito, Haruhiro ^{[1
]}

Sakuma, Yuji ^{[3
]}

Matsukuma, Shoichi ^{[3
]}

Hasegawa, Chikako ^{[2
]}

Kondo, Tetsuro ^{[1
]}

Oshita, Fumihiro ^{[1
]}

Ito, Hiroyuki ^{[1
]}

Tsuboi, Masahiro ^{[1
]}

Nakayama, Haruhiko ^{[1
]}

Kameda, Youichi ^{[2
]}

Noda, Kazumasa ^{[1
]}

Yamada, Kouzo ^{[1
]}

机构：

[1] Kanagawa Canc Ctr Hosp, Dept Thorac Oncol, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[2] Kanagawa Canc Ctr Hosp, Dept Pathol, Yokohama, Kanagawa 2410815, Japan

[3] Kanagawa Canc Res Inst, Mol Pathol & Genet Div, Kanagawa, Japan

来源：

LUNG CANCER | 2010年 / 69卷 / 03期

关键词：

EML4-ALK; Adenocarcinoma; Signet-ring cell; Recurrence; CANCER; EML4-ALK; MUTATIONS; FEATURES;

D O I：

10.1016/j.lungcan.2010.05.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The fusion gene EML4-ALK (echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene) was recently identified as a novel genetic alteration in non-small-cell lung cancer. The clinicopathological features of EML4-ALK-positive adenocarcinoma are reported to include its high incidence in young, non-smoking patients, tumors that show distinct solid or acinar growth patterns with or without signet-ring cell histology, and its mutually exclusive occurrence with mutations in EGFR and KRAS. However, the clinical findings have not been well described. Here, we report a case of EML4-ALK-positive lung adenocarcinoma that showed multiple metachronous lesions on the pleura and pulmonary field, suspected to be a recurrence of lung adenocarcinoma after a 20-year disease-free interval. The slow clinical course may be characteristic of EML4-ALK-positive lung adenocarcinoma. Therefore, long-term observation of patients with EML4-ALK-positive lung adenocarcinomas is required after surgery. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：361 / 364

页数：4

共 12 条

[1] Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas [J].

Boland, Jennifer M. ;

Erdogan, Sibel ;

Vasmatzis, George ;

Yang, Ping ;

Tillmans, Lori S. ;

Johnson, Michele R. Erickson ;

Wang, Xiaoke ;

Peterson, Lisa M. ;

Halling, Kevin C. ;

Oliveira, Andre M. ;

Aubry, Marie Christine ;

Yi, Eunhee S. .

HUMAN PATHOLOGY, 2009, 40 (08) :1152-1158

[2] Use of Epidermal Growth Factor Receptor/Kirsten Rat Sarcoma 2 Viral Oncogene Homolog Mutation Testing to Define Clonal Relationships Among Multiple Lung Adenocarcinomas Comparison With Clinical Guidelines [J].

Girard, Nicolas ;

Deshpande, Charuhas ;

Azzoli, Christopher G. ;

Rusch, Valerie W. ;

Travis, William D. ;

Ladanyi, Marc ;

Pao, William .

CHEST, 2010, 137 (01) :46-52

[3] Comprehensive Histologic Assessment Helps to Differentiate Multiple Lung Primary Nonsmall Cell Carcinomas From Metastases [J].

Girard, Nicolas ;

Deshpande, Charuhas ;

Lau, Christopher ;

Finley, David ;

Rusch, Valerie ;

Pao, William ;

Travis, William D. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (12) :1752-1764

[4] EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset [J].

Inamura, Kentaro ;

Takeuchi, Kengo ;

Togashi, Yuki ;

Hatano, Satoko ;

Ninomiya, Hironori ;

Motoi, Noriko ;

Mun, Ming-yon ;

Sakao, Yukinori ;

Okumura, Sakae ;

Nakagawa, Ken ;

Soda, Manabu ;

Choi, Young Lim ;

Mano, Hiroyuki ;

Ishikawa, Yuichi .

MODERN PATHOLOGY, 2009, 22 (04) :508-515

[5]

MARTINI N, 1975, J THORAC CARDIOV SUR, V70, P606

[6] Rapid and simple detection of hot spot point mutations of epidermal growth factor receptor, BRAF, and NRAS in cancers using the loop-hybrid mobility shift assay [J].

Matsukuma, Shoichi ;

Yoshihara, Mitsuyo ;

Kasai, Furnio ;

Kato, Akinori ;

Yoshida, Akira ;

Akaike, Makoto ;

Kobayashi, Osamu ;

Nakayama, Haruhiko ;

Sakuma, Yuji ;

Yoshida, Tsutomu ;

Kameda, Yoichi ;

Tsuchiya, Eiju ;

Miyagi, Yohei .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2006, 8 (04) :504-512

[7] Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer [J].

Rikova, Klarisa ;

Guo, Ailan ;

Zeng, Qingfu ;

Possemato, Anthony ;

Yu, Jian ;

Haack, Herbert ;

Nardone, Julie ;

Lee, Kimberly ;

Reeves, Cynthia ;

Li, Yu ;

Hu, Yerong ;

Tan, Zhiping ;

Stokes, Matthew ;

Sullivan, Laura ;

Mitchell, Jeffrey ;

Wetzel, Randy ;

MacNeill, Joan ;

Ren, Jian Min ;

Yuan, Jin ;

Bakalarski, Corey E. ;

Villen, Judit ;

Kornhauser, Jon M. ;

Smith, Bradley ;

Li, Daiqiang ;

Zhou, Xinmin ;

Gygi, Steven P. ;

Gu, Ting-Lei ;

Polakiewicz, Roberto D. ;

Rush, John ;

Comb, Michael J. .

CELL, 2007, 131 (06) :1190-1203

[8] Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population [J].

Rodig, Scott J. ;

Mino-Kenudson, Mari ;

Dacic, Sanja ;

Yeap, Beow Y. ;

Shaw, Alice ;

Barletta, Justine A. ;

Stubbs, Hannah ;

Law, Kenny ;

Lindeman, Neal ;

Mark, Eugene ;

Janne, Pasi A. ;

Lynch, Thomas ;

Johnson, Bruce E. ;

Iafrate, A. John ;

Chirieac, Lucian R. .

CLINICAL CANCER RESEARCH, 2009, 15 (16) :5216-5223

[9] Follow-up and surveillance of the lung cancer patient following curative intent therapy - ACCP evidence-based clinical practice guideline (2nd edition) [J].

Rubins, Jeffrey ;

Unger, Michael ;

Colice, Gene L. .

CHEST, 2007, 132 (03) :355S-367S

[10] Clinical Features and Outcome of Patients With Non-Small-Cell Lung Cancer Who Harbor EML4-ALK [J].

Shaw, Alice T. ;

Yeap, Beow Y. ;

Mino-Kenudson, Mari ;

Digumarthy, Subba R. ;

Costa, Daniel B. ;

Heist, Rebecca S. ;

Solomon, Benjamin ;

Stubbs, Hannah ;

Admane, Sonal ;

McDermott, Ultan ;

Settleman, Jeffrey ;

Kobayashi, Susumu ;

Mark, Eugene J. ;

Rodig, Scott J. ;

Chirieac, Lucian R. ;

Kwak, Eunice L. ;

Lynch, Thomas J. ;

Iafrate, A. John .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (26) :4247-4253

← 1 2 →