Strain and stage specific variation in Toxoplasma gondii antigens

被引：13

作者：

Appleford, PJ ^{[1
]}

Smith, JE ^{[1
]}

机构：

[1] Univ Leeds, Sch Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2000年 / 30卷 / 11期

基金：

英国医学研究理事会;

关键词：

Toxoplasma gondii; tachyzoites; bradyzoites; antigens; strain variation; polymorphism;

D O I：

10.1016/S0020-7519(00)00109-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The antigenic profile of virulent (RH, ENT, Martin) and avirulent (RRA, DEG, ME49) Toxoplasma strains was compared directly by western blotting using a panel of immune mouse sera. Dominant antigens of approximate MR 30-33, 21 and 25 x 10(3) were common to tachyzoites of all strains, however, there were significant quantitative and qualitative differences in the antigen profiles, indicating a moderate degree of strain specific polymorphism in tachyzoite antigens. We found no specific association between antigenic variation and strain virulence. Comparison of tachyzoite and bradyzoite antigens from homologous strains (RRA, DEG, ME49) confirmed the existence of stage specific antigens and demonstrated a conserved antigen profile among bradyzoites. (C) 2000 Published by Elsevier Science Ltd. on behalf of the Australian Society for Parasitology.

引用

页码：1187 / 1191

页数：5

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