Heat Shock Proteins Promote Cancer: It's a Protection Racket

被引：380

作者：

Calderwood, Stuart K. ^{[1
]}

Gong, Jianlin ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, CLS610,300 Brookline Ave, Boston, MA 02215 USA

[2] Boston Univ, Dept Med, Boston, MA 02118 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 04期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR HSF1; PROSTATE-CANCER; MAMMARY-TUMORS; GASTRIC-CANCER; SECRETED HSP90; CELL-DEATH; HSP70; HSP27; METASTASIS;

D O I：

10.1016/j.tibs.2016.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering environment that is essential for tumor development. Here, we review the recent data in this area, concentrating mainly on Hsp27, Hsp70, and Hsp90. The overriding role of HSPs in cancer is to stabilize the active functions of over expressed and mutated cancer genes. Thus, elevated HSPs are required for many of the traits that underlie the morbidity of cancer, including increased growth, survival, and formation of secondary cancers. In addition, HSPs participate in the evolution of cancer treatment resistance. HSPs are also released from cancer cells and influence malignant properties by receptor-mediated signaling. Current data strongly support efforts to target HSPs in cancer treatment.

引用

页码：311 / 323

页数：13

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