A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle

被引：48

作者：

Weibel, L

Turek, FW

Mocaer, E

Van Reeth, O

机构：

[1] Free Univ Brussels, Hop Erasme, Sch Med, Ctr Etud Rythmes Biol, B-1070 Brussels, Belgium

[2] SERVIER, Inst Rech Int, Courbevoie, France

来源：

BRAIN RESEARCH | 2000年 / 880卷 / 1-2期

关键词：

circadian clock; aging; jet lag; melatonin; agonist; re-entrainment;

D O I：

10.1016/S0006-8993(00)02806-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shift?, in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by similar to 25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：207 / 211

页数：5

共 24 条

[1] Efficacy of melatonin treatment in jet lag, shift work, and blindness [J].