Distribution of the 4F2 light chain, LATI, in the mouse brain

被引：25

作者：

Kageyama, T

Imura, T

Matsuo, A

Minato, N

Shimohama, S

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Immunol & Cell Biol, Sakyo Ku, Kyoto 6068507, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 17期

关键词：

4F2; CD98; LATI; neurogenesis; system L;

D O I：

10.1097/00001756-200011270-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LAT1 (the 4F2-light chain I) is a component of the CD98 surface antigen which participates in multiple functions including amino acid transport, cell survival, cell fusion and integrin activation. We examined the distribution of LAT1 in the mouse brain using immunohistochemistry. LAT1 was expressed on the microvessels, the subfornical organ, the subcommissural organ, ventromedial nucleus of the hypothalamus, subgranular zone of the dentate gyrus, ependymal layer of the lateral ventricles, and the olfactory bulb. LAT1-positive cells incorporated bromodeoxyuridine in the latter three regions where neurogenesis occurs in adult mouse brain, indicating that LAT1 is involved in neuronal cell proliferation, as well as in amino acid transport in these regions. NeuroReport 11:3663-3666 (C) 2000 Lippincott Williams & Wilkins.

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收藏

页码：3663 / 3666

页数：4

相关论文

共 25 条

[1] Distinct functions of α3 and αv integrin receptors in neuronal migration and laminar organization of the cerebral cortex [J].

Anton, ES ;

Kreidberg, JA ;

Rakic, P .

NEURON, 1999, 22 (02) :277-289

[2] Selective expression of the large neutral amino acid transporter at the blood-brain barrier [J].

Boado, RJ ;

Li, JY ;

Nagaya, M ;

Zhang, C ;

Pardridge, WM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :12079-12084

[3] TA1/LAT-1/CD98 light chain and system L activity, but not 4F2/CD98 heavy chain, respond to arginine availability in rat hepatic cells - Loss of response in tumor cells [J].

Campbell, WA ;

Sah, DE ;

Medina, MM ;

Albina, JE ;

Coleman, WB ;

Thompson, NL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (08) :5347-5354

[4] Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by α3β1 integrin and regulated by insulin-like growth factor-1 and CD98 [J].

Chandrasekaran, S ;

Guo, NH ;

Rodrigues, RG ;

Kaiser, J ;

Roberts, DD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :11408-11416

[5] Developmental changes in integrin beta-subunits in rat cerebral cortex [J].

Cousin, B ;

Leloup, C ;

Penicaud, L ;

Price, J .

NEUROSCIENCE LETTERS, 1997, 234 (2-3) :161-165

[6] Complementation of dominant suppression implicates CD98 in integrin activation [J].

Fenczik, CA ;

Sethi, T ;

Ramos, JW ;

Hughes, PE ;

Ginsberg, MH .

NATURE, 1997, 390 (6655) :81-85

[7] Malignant transformation of NIH3T3 cells by overexpression of early lymphocyte activation antigen CD98 [J].

Hara, K ;

Kudoh, H ;

Enomoto, T ;

Hashimoto, Y ;

Masuko, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 262 (03) :720-725

[8] Identification of a neural stem cell in the adult mammalian central nervous system [J].

Johansson, CB ;

Momma, S ;

Clarke, DL ;

Risling, M ;

Lendahl, U ;

Frisén, J .

CELL, 1999, 96 (01) :25-34

[9] SENSORY CIRCUMVENTRICULAR ORGANS AND BRAIN HOMEOSTATIC PATHWAYS [J].

JOHNSON, AK ;

GROSS, PM .

FASEB JOURNAL, 1993, 7 (08) :678-686

[10] Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98) [J].

Kanai, Y ;

Segawa, H ;

Miyamoto, K ;

Uchino, H ;

Takeda, E ;

Endou, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) :23629-23632