Pseudoscleroderma associated with lung cancer: correlation of collagen type T and connective tissue growth factor gene expression

被引：32

作者：

Querfeld, C ^{[1
]}

Sollberg, S ^{[1
]}

Huerkamp, C ^{[1
]}

Eckes, B ^{[1
]}

Krieg, T ^{[1
]}

机构：

[1] Univ Cologne, Klin & Poliklin Dermatol & Venerol, Dept Dermatol, D-50924 Cologne, Germany

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2000年 / 142卷 / 06期

关键词：

alpha 1(I)-collagen; connective tissue growth factor; paraneoplasm; pseudoscleroderma; squamous cell carcinoma;

D O I：

10.1046/j.1365-2133.2000.03579.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis, Using in situ hybridization, marked expression of alpha 1(I)-collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis, However, transforming growth factor (TGF)-beta 1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF-beta 1 mRNA could indicate that tumour-derived factors induce the expression of CTGF.

引用

页码：1228 / 1233

页数：6

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