Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines

被引：55

作者：

Sadashiva, MP

Mallesha, H

Hitesh, NA

Rangappa, KS ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

[2] Univ Mysore, Dept Studies Biochem, Mysore 570006, Karnataka, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 24期

关键词：

antimicrobial properties; synthesis; nitrones; isoxazolidine derivatives; cycloaddition;

D O I：

10.1016/j.bmc.2004.09.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Cycloaddition of C-imidazolyl-N-phenylnitrotles with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against E moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6389 / 6395

页数：7

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