Ceramide-rich platforms in transmembrane signaling

被引：234

作者：

Stancevic, Branka ^{[1
]}

Kolesnick, Richard ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab Signal Transduct, New York, NY 10021 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

关键词：

Ceramide; Platforms; ASMase; PROTEIN-KINASE-C; RADIATION-INDUCED APOPTOSIS; ACID SPHINGOMYELINASE GENE; ENRICHED MEMBRANE PLATFORMS; VASCULAR ENDOTHELIAL-CELLS; INDUCED INSULIN-RESISTANCE; STRESS-INDUCED APOPTOSIS; HUMAN EPITHELIAL-CELLS; GH3; PITUITARY-CELLS; LIPID RAFTS;

D O I：

10.1016/j.febslet.2010.02.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence suggests that ceramide regulates stress signaling via reorganization of the plasma membrane. The focus of this review will be to discuss the mechanism by which acid sphingomyelinase (ASMase)-generated ceramide initiates transmembrane signaling in the plasma membrane exoplasmic leaflet. In particular, we review the unique biophysical properties of ceramide that render it proficient in formation of signaling domains termed ceramide-rich platforms (CRPs), and the role of CRPs in the pathophysiology of various diseases. The biomedical significance of CRPs makes these structures an attractive therapeutic target. (C) 2010 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.

引用

页码：1728 / 1740

页数：13

共 160 条

[1] Searching for the molecular arrangement of transmembrane ceramide channels [J].

Anishkin, A ;

Sukharev, S ;

Colombini, M .

BIOPHYSICAL JOURNAL, 2006, 90 (07) :2414-2426

[2] Measurement of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles [J].

Bai, JN ;

Pagano, RE .

BIOCHEMISTRY, 1997, 36 (29) :8840-8848

[3] Morphological changes induced by phospholipase C and by sphingomyelinase on large unilamellar vesicles: A cryo-transmission electron microscopy study of liposome fusion [J].

Basanez, G ;

RuizArguello, MB ;

Alonso, A ;

Goni, FM ;

Karlsson, G ;

Edwards, K .

BIOPHYSICAL JOURNAL, 1997, 72 (06) :2630-2637

[4] Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains [J].

Bezombes, C ;

Grazide, S ;

Garret, C ;

Fabre, C ;

Quillet-Mary, A ;

Müller, S ;

Jaffrézou, JP ;

Laurent, G .

BLOOD, 2004, 104 (04) :1166-1173

[5] Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria? [J].

Bionda, C ;

Portoukalian, J ;

Schmitt, D ;

Rodriguez-Lafrasse, C ;

Ardail, D .

BIOCHEMICAL JOURNAL, 2004, 382 :527-533

[6] Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering [J].

Bionda, Clara ;

Hadchity, Elie ;

Alphonse, Gersende ;

Chapet, Olivier ;

Rousson, Robert ;

Rodriguez-Lafrasse, Claire ;

Ardail, Dominique .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 43 (05) :681-694

[7] The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts [J].

Bock, J ;

Gulbins, E .

FEBS LETTERS, 2003, 534 (1-3) :169-174

[8] CD28 SIGNALS THROUGH ACIDIC SPHINGOMYELINASE [J].

BOUCHER, LM ;

WIEGMANN, K ;

FUTTERER, A ;

PFEFFER, K ;

MACHLEIDT, T ;

SCHUTZE, S ;

MAK, TW ;

KRONKE, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (06) :2059-2068

[9] The skin barrier in healthy and diseased state [J].

Bouwstra, Joke A. ;

Ponec, Maria .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (12) :2080-2095

[10] Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases [J].

Brenner, B ;

Ferlinz, K ;

Grassmé, H ;

Weller, M ;

Koppenhoefer, U ;

Dichgans, J ;

Sandhoff, K ;

Lang, F ;

Gulbins, E .

CELL DEATH AND DIFFERENTIATION, 1998, 5 (01) :29-37

← 1 2 3 4 5 6 7 8 9 10 →