Association of Vitamin D With Insulin Resistance and β-Cell Dysfunction in Subjects at Risk for Type 2 Diabetes

被引：271

作者：

Kayaniyil, Sheena ^{[1
]}

Vieth, Reinhold ^{[1
,2
]}

Retnakaran, Ravi ^{[3
]}

Knight, Julia A. ^{[4
,5
]}

Qi, Ying ^{[3
]}

Gerstein, Hertzel C. ^{[6
,7
,8
]}

Perkins, Bruce A. ^{[3
]}

Harris, Stewart B. ^{[9
]}

Zinman, Bernard ^{[3
,5
]}

Hanley, Anthony J. ^{[1
,3
,4
]}

机构：

[1] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Div Endocrinol, Toronto, ON, Canada

[4] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[5] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[6] McMaster Univ, Dept Med, Div Endocrinol & Metab, Hamilton, ON, Canada

[7] McMaster Univ, Dept Med, Populat Hlth Res Inst, Hamilton, ON, Canada

[8] Hamilton Hlth Sci, Hamilton, ON, Canada

[9] Univ Western Ontario, Ctr Studies Family Med, London, ON, Canada

来源：

DIABETES CARE | 2010年 / 33卷 / 06期

基金：

加拿大健康研究院;

关键词：

25-HYDROXYVITAMIN D; D DEFICIENCY; GLUCOSE; SECRETION; MARKERS; ADULTS;

D O I：

10.2337/dc09-2321

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS - Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin sensitivity/resistance were measured using the Matsuda insulin sensitivity index for oral glucose tolerance tests (ISOGTT) and homeostasis model assessment of insulin resistance HOMA-IR. beta-Cell function was determined using both the insulinogenic index (IGI) divided by HOMA-IR (IGI/IR) and the insulin secretion sensitivity index-2 (ISSI-2). RESULTS - Linear regression analyses indicated independent associations of 25(OH)D with ISOGTT and HOMA-IR (beta = 0.004, P = 0.0003, and beta = -0.003, P = 0.0072, respectively) and with IGI/IR and ISSI-2 (beta = 0.004, P = 0.0286, and beta = 0.003, P = 0.0011, respectively) after adjusting for sociodemographics, physical activity, supplement use, parathyroid hormone, and BMI. CONCLUSIONS - Vitamin D may play a role in the pathogenesis of type 2 diabetes, as 25(OH)D concentration was independently associated with both insulin sensitivity and beta-cell function among individuals at risk of type 2 diabetes.

引用

页码：1379 / 1381

页数：3

共 15 条

[1] GLUCOSE-INTOLERANCE AND IMPAIRMENT OF INSULIN-SECRETION IN RELATION TO VITAMIN-D DEFICIENCY IN EAST LONDON ASIANS [J].