Recognition of DNA by octahedral coordination complexes

被引：62

作者：

Johann, TW

Barton, JK

机构：

[1] Div. of Chem. and Chem. Engineering, California Institute of Technology, Pasadena

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 1996年 / 354卷 / 1706期

关键词：

D O I：

10.1098/rsta.1996.0010

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Strategies for the site-specific recognition of DNA are described through the design of a family of octahedral metallointercalating complexes. Coordination complexes, which mimic DNA-binding proteins with regard to their affinity and specificity for DNA sites, may be prepared by the specific functionalization of chiral metal complexes so as to achieve the ensemble of non-covalent contacts in the DNA major groove anchored through intercalation.

引用

收藏

页码：299 / 324

页数：26

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