Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis

被引：41

作者：

Fort, DM ^{[1
]}

Ubillas, RP ^{[1
]}

Mendez, CD ^{[1
]}

Jolad, SD ^{[1
]}

Inman, WD ^{[1
]}

Carney, JR ^{[1
]}

Chen, JL ^{[1
]}

Ianiro, TT ^{[1
]}

Hasbun, C ^{[1
]}

Bruening, RC ^{[1
]}

Luo, J ^{[1
]}

Reed, MJ ^{[1
]}

Iwu, M ^{[1
]}

Carlson, TJ ^{[1
]}

King, SR ^{[1
]}

Bierer, DE ^{[1
]}

Cooper, R ^{[1
]}

机构：

[1] Shaman Pharmaceut Inc, S San Francisco, CA 94080 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 20期

关键词：

D O I：

10.1021/jo000568q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.

引用

页码：6534 / 6539

页数：6

共 28 条

[1] MEDICINAL-PLANTS USED BY THE FANG TRADITIONAL HEALERS IN EQUATORIAL-GUINEA [J].