Primary resistance mutations to fusion inhibitors and polymorphisms in gp4l sequences of HIV-1 non-B subtypes and recombinants

被引:21
作者
Villahermosa, ML [1 ]
Perez-Alvarez, L
Carmona, R
Cuevas, MT
Thomson, MM
Medrano, L
de Parga, EV
Delgado, E
Pedreira, JD
Njera, R
机构
[1] Inst Salud Carlos III, Madrid, Spain
[2] Hosp Juan Canalejo, La Coruna, Spain
关键词
D O I
10.1097/00002030-200305020-00020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Primary resistance mutations to fusion inhibitors and polymorphisms in gp41 sequences of non-B subtypes and recombinant HIV-1 isolates were analysed. L91H to RPR103611 was detected in one DG(pol)/D-env/D-gp41 recombinant; L9F and K144R, rarely reported previously, were frequent in the B region of CRF14_BG recombinants. V194I and V318A, not described in the G subtype, were detected in the G region of BG recombinants and in G subtype viruses that also show the rare mutations T115L, M118V and K90R.
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收藏
页码:1083 / 1086
页数:4
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