P18 tumor suppressor gene and progression of oligodendrogliomas to anaplasia

被引：16

作者：

He, J

Hoang-Xuan, K

Marie, Y

Leuraud, P

Mokhtari, K

Kujas, M

Delattre, JY

Sanson, M

机构：

[1] Hop La Pitie Salpetriere, Neurol Clin, INSERM, U495, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, Federat Neurol Mazarin, F-75013 Paris, France

[3] Hop La Pitie Salpetriere, Lab Neuropathol R Escourolle, F-75013 Paris, France

[4] Hop La Pitie Salpetriere, Lab Histol Embryol Cytogenet, Paris, France

来源：

NEUROLOGY | 2000年 / 55卷 / 06期

关键词：

D O I：

10.1212/WNL.55.6.867

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P18(INK4C) is a good candidate to be the tumor suppressor gene involved in oligodendrogliomas on 1p32. Loss of heterozygosity on Ip, mutation(s), homozygous deletion(s), and expression of p18 in 30 oligodendroglial tumors were investigated. Loss of heterozygosity on Ip was found in 15 tumors. A p18 mutation was found at an recurrence of an anaplastic oligodendroglioma, but not in the primary, low-grade tumor. No homozygous deletions were found and p18 was expressed in all cases. These results show that p18 alteration is involved in tumor progression in a subset of oligodendrogliomas.

引用

页码：867 / 869

页数：3

共 10 条

[1] Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer [J].