Treatment of hepatitis C virus infection

被引：24

作者：

Weigand, Kilian ^{[1
]}

Stremmel, Wolfgang ^{[1
]}

Encke, Jens ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Gastroenterol & Hepatol, D-69120 Heidelberg, Germany

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 13期

关键词：

hepatitis C virus; acute and chronic HCV infection; treatment; pegylated interferon; ribavirin; sustained virologic response; non-responders; relapsers;

D O I：

10.3748/wjg.v13.i13.1897

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acute and chronic hepatitis C virus (HCV) infection remains a serious health problem worldwide, however, there has been advancement in the treatment of HCV infection due to standard treatment using pegylated interferon and ribavirin. The literature indicates that therapy for HCV is becoming more individualized. In addition to considering genotype and viral RNA levels before treatment, achievement of an early virologic response (EVR) and a rapid virologic response (RVR) is now possible during therapy. Moreover, problem patients, such as non-responders, relapsers, HIV or HBV coinfected patients, patients with liver cirrhosis, and pre-or post-liver transplantation patients are an increasing fraction of the patients requiring treatment. This article reviews the literature regarding standard treatments and problem patients with acute and chronic HCV infection. It also includes discussion on contraindications and side effects of treatment with interferon and ribavirin, as well as new drug development. (C) 2007 The WJG Press. All rights reserved.

引用

页码：1897 / 1905

页数：9

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