Twenty years of naproxen technology

被引：264

作者：

Harrington, PJ ^{[1
]}

Lodewijk, E ^{[1
]}

机构：

[1] Syntex Grp, Ctr Technol, Boulder, CO 80301 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1997年 / 1卷 / 01期

关键词：

D O I：

10.1021/op960009e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This review includes (1) a discussion of marketing and manufacturing of optically pure pharmaceuticals including naproxen, (2) an historical overview of Syntex naproxen manufacturing technology, (3) a comparison of classical resolution and asymmetric technologies specific to naproxen manufacture, (4) a cost comparison of naproxen starting materials, (5) data on the Syntex resolution technology and the impact of continuous process research and development on that technology, and (6) some environmental aspects of naproxen manufacturing.

引用

页码：72 / 76

页数：5

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