New methods for analyzing compounds on polymeric supports

被引：143

作者：

Gallop, MA ^{[1
]}

Fitch, WL ^{[1
]}

机构：

[1] Affymax Res Inst, Palo Alto, CA 94304 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(97)80114-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beyond specialized applications in peptide and oligonucleotide synthesis, widespread utilization of solid-phase methods in organic chemistry has been hampered by a lack of powerful analytical methods for characterization of polymer-supported compounds. The advent of combinatorial organic synthesis has recently spawned efforts to develop spectroscopic techniques such as infrared spectrometry, mass spectrometry and nuclear magnetic resonance as routine tools for structure elucidation in solid-phase synthesis.

引用

页码：94 / 100

页数：7

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