Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

被引：34

作者：

Dinkova-Kostova, Albena T. ^{[1
,3
]}

Fahey, Jed W. ^{[1
,2
]}

Benedict, Andrea L. ^{[1
]}

Jenkins, Stephanie N. ^{[1
]}

Ye, Lingxiang ^{[1
]}

Wehage, Scott L. ^{[1
]}

Talalay, Paul ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Lewis B & Dorothy Cullman Canc Chemoprotect Ctr, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Publ Hlth, Ctr Human Nutr, Baltimore, MD 21205 USA

[3] Univ Dundee, Biomed Res Inst, Dundee DD1 9SY, Scotland

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2010年 / 9卷 / 04期

关键词：

MOUSE SKIN; SULFORAPHANE; INHIBITION; ISOTHIOCYANATES; TUMORIGENESIS; SUPPRESSION; ENZYMES; TUMORS; RISK;

D O I：

10.1039/b9pp00130a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Feeding broccoli sprout extracts providing daily doses of 10 mu mol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

引用

页码：597 / 600

页数：4

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