The role of drug transporters at the blood-brain barrier

被引：168

作者：

de Boer, AG ^{[1
]}

van der Sandt, ICJ ^{[1
]}

Gaillard, PJ ^{[1
]}

机构：

[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Pharmacol, Blood Brain Barrier Res Grp, NL-2300 RA Leiden, Netherlands

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2003年 / 43卷

关键词：

P-glycoprotein; multidrug-resistance proteins; transferrin receptor; scavenger receptors; large amino acid transporters; nucleoside transporters; anion transporters;

D O I：

10.1146/annurev.pharmtox.43.100901.140204

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The blood-brain barrier (BBB) is a dynamic interface between the blood and the brain, It eliminates (toxic) substances from the endothelial compartment and supplies the brain with nutrients and other (endogenous) compounds. It can be considered as an organ protecting the brain and regulating its homeostasis. Until now, many transport systems have been discovered that play an important role in maintaining BBB integrity and brain homeostasis. In this review, we focus on the role of carrier- and receptor-mediated transport systems (CMT, RMT) at the BBB. These include CMT systems, such as P-glycoprotein, multidrug-resistance proteins 1-7, nucleoside transporters, organic anion transporters, and large amino-acid transporters; RMT systems, such as the transferrin-1 and -2 receptors; and the scavenger receptors SB-AI and SB-BI.

引用

页码：629 / 656

页数：30

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