Neutrophil granulocytes -: Trojan horses for Leishmania major and other intracellular microbes?

被引:185
作者
Laskay, T [1 ]
van Zandbergen, G [1 ]
Solbach, W [1 ]
机构
[1] Med Univ Lubeck, Inst Med Microbiol & Hyg, D-23538 Lubeck, Germany
关键词
D O I
10.1016/S0966-842X(03)00075-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polymorphonuclear neutrophil granulocytes (PMNs) possess numerous effector mechanisms to kill ingested pathogens as the first line of defence. However, several microorganisms evade intracellular killing in neutrophils, survive and retain infectivity. There is increasing evidence that several pathogens even multiply within neutrophils. Taking Leishmania major as a prototypic intracellular pathogen, we suggest an evasion strategy that includes the manipulation of PMNs in such a way that the pathogens are able to use the granulocytes as host cells. The ability to survive and maintain infectivity in PMNs subsequently enables these organisms to establish productive infection. These organisms can use granulocytes as Trojan horses before they enter their definitive host cells, the macrophages.
引用
收藏
页码:210 / 214
页数:5
相关论文
共 50 条
[1]   Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major [J].
Aga, E ;
Katschinski, DM ;
van Zandbergen, G ;
Laufs, H ;
Hansen, B ;
Müller, K ;
Solbach, W ;
Laskay, T .
JOURNAL OF IMMUNOLOGY, 2002, 169 (02) :898-905
[2]   Regulated production of the interferon-gamma-inducible protein-10 (IP-10) chemokine by human neutrophils [J].
Cassatella, MA ;
Gasperini, S ;
Calzetti, F ;
Bertagnin, A ;
Luster, AD ;
McDonald, PP .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (01) :111-115
[3]   Molecular machinations: Chemokine signals in host-pathogen interactions [J].
Chensue, SW .
CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (04) :821-835
[4]   Intracellular Salmonella typhimurium induce lysis of human polymorphonuclear leukocytes which is not associated with the Salmonella virulence plasmid [J].
Chiu, CH ;
Ou, JT .
MICROBIOLOGY AND IMMUNOLOGY, 1999, 43 (01) :9-14
[5]  
COLOTTA F, 1992, BLOOD, V80, P2012
[6]   BOVINE NEUTROPHILS INGEST BUT DO NOT KILL HEMOPHILUS-SOMNUS INVITRO [J].
CZUPRYNSKI, CJ ;
HAMILTON, HL .
INFECTION AND IMMUNITY, 1985, 50 (02) :431-436
[7]   Apoptosis and parasitism: from the parasite to the host immune response [J].
DosReis, GA ;
Barcinski, MA .
ADVANCES IN PARASITOLOGY, VOL 49, 2001, 49 :133-161
[8]   A SAFE-SITE FOR SALMONELLA-TYPHIMURIUM IS WITHIN SPLENIC POLYMORPHONUCLEAR CELLS [J].
DUNLAP, NE ;
BENJAMIN, WH ;
BERRY, AK ;
ELDRIDGE, JH ;
BRILES, DE .
MICROBIAL PATHOGENESIS, 1992, 13 (03) :181-190
[9]   Burkholderia pseudomallei activates complement and is ingested but not killed by polymorphonuclear leukocytes [J].
Egan, AM ;
Gordon, DL .
INFECTION AND IMMUNITY, 1996, 64 (12) :4952-4959
[10]  
FADOK VA, 1992, J IMMUNOL, V148, P2207