Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey

被引:126
作者
Morris, MS [1 ]
Jacques, PF [1 ]
Selhub, J [1 ]
Rosenberg, IH [1 ]
机构
[1] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
关键词
cardiovascular diseases; estrogen replacement therapy; homocysteine; menopause; premenopause;
D O I
10.1093/aje/152.2.140
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The possibility that estrogen status modulates total homocysteine concentration, a risk factor for vascular occlusion, was examined in a representative sample of the US population, the Third National Health and Nutrition Examination Survey (phase 2), 1991-1994. The geometric mean serum total homocysteine concentration was compared among population subgroups differing on inferred estrogen status, after adjusting for potential confounding by age, race-ethnicity, smoking, and the serum concentration of creatinine, folate, and vitamin B-12. Premenopausal women aged 17-54 years had a lower mean serum total homocysteine concentration (8.1 mu mol/liter, 95% confidence interval (CI): 7.9, 8.2) than men in the same age range (8.9 mu mol/liter, 95% CI: 8.6, 9.3). In the age range 17-44 years, pregnant women (6.0 mu mol/liter, 95% CI: 5.4, 6.8), but not oral contraceptive users (7.9 mu mol/liter, 95% CI: 7.6, 8.2), had a lower mean serum total homocysteine concentration than nonpregnant, non-oral-contraceptive-using women (8.1 mu mol/liter, 95% CI: 7.9, 8.2). The mean serum total homocysteine concentration of estrogen-using women aged greater than or equal to 55 years (9.5 mu mol/liter, 95% CI: 8.9, 10.1) was significantly decreased relative to nonestrogen users (10.7 mu mol/liter, 95% CI: 10.3, 11.1) and men (10.4 mu mol/liter, 95% CI: 9.8, 11.0) in the same age range. These findings suggest that higher estrogen status is associated with a decreased mean serum total homocysteine concentration, independent of nutritional status and muscle mass, and that estrogen may explain the previously reported male-female difference in total homocysteine concentration.
引用
收藏
页码:140 / 148
页数:9
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