The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: Implications for cancer, shock, and inflammatory diseases

被引：80

作者：

Furusawa, Shinobu

Wu, Jianghong

机构：

[1] Tohoku Pharmaceut Univ, Pharmaceut Educ Ctr, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

LIFE SCIENCES | 2007年 / 80卷 / 12期

关键词：

cepharanthine; biscoclaurine alkaloid; multidrug resistance; antitumor; apoptosis; anti-inflammatory;

D O I：

10.1016/j.lfs.2006.12.001

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The extract of Stephania cepharantha Hayata contains biscoclaurine alkaloids such as cepharanthine, which have been used widely in Japan for the treatment of patients with radiation-induced leukopenia, alopecia areata, exudative otitis media, and venomous snakebites. Many investigations have proven that the alkaloid cepharanthine exerts diverse pharmacological effects that include membrane-stabilizing, multidrug resistance-reversing, antitumor, apoptosis-inducing, anti-inflammatory, free radical scavenging, anti-HIV-1, antiallergic and immunomodulatory effects. The purpose of our review is to describe various therapeutic approaches using cepharanthine and their potential efficacy. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1073 / 1079

页数：7

共 80 条

[1] CHEMOSENSITISATION OF SPONTANEOUS MULTIDRUG-RESISTANCE BY A 1,4-DIHYDROPYRIDINE ANALOG AND VERAPAMIL IN HUMAN GLIOMA CELL-LINES OVEREXPRESSING MRP OR MDR1 [J].