Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: A longitudinal study

被引:216
作者
Censits, DM [1 ]
Ragland, JD [1 ]
Gur, RC [1 ]
Gur, RE [1 ]
机构
[1] UNIV PENN HLTH SYST,PHILADELPHIA,PA 19104
关键词
neuropsychology; neurodevelopment; schizophrenia;
D O I
10.1016/S0920-9964(96)00091-6
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.
引用
收藏
页码:289 / 298
页数:10
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