Unravelling mononuclear phagocyte heterogeneity

被引：408

作者：

Geissmann, Frederic ^{[1
]}

Gordon, Siamon ^{[2
]}

Hume, David A. ^{[3
,4
]}

Mowat, Allan M. ^{[5
]}

Randolph, Gwendalyn J. ^{[6
]}

机构：

[1] Kings Coll London, London SE1 1UL, England

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[3] Univ Edinburgh, Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[4] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian, Scotland

[5] Univ Glasgow, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland

[6] Mt Sinai Sch Med, New York, NY 10029 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 06期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

DERMAL DENDRITIC CELLS; MOUSE BONE-MARROW; LAMINA-PROPRIA; IN-VIVO; MACROPHAGE ACTIVATION; IMMUNE-RESPONSES; LANGERHANS CELLS; MONOCYTE SUBSETS; EPITHELIAL-CELLS; DIFFERENTIATION;

D O I：

10.1038/nri2784

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research.

引用

收藏

页码：453 / U92

页数：8

相关论文

共 64 条

[1] Local self-renewal can sustain CNS microglia maintenance and function throughout adult life [J].

Ajami, Bahareh ;

Bennett, Jami L. ;

Krieger, Charles ;

Tetzlaff, Wolfram ;

Rossi, Fabio M. V. .

NATURE NEUROSCIENCE, 2007, 10 (12) :1538-1543

[2] Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells [J].

Auffray, Cedric ;

Sieweke, Michael H. ;

Geissmann, Frederic .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :669-692

[3]

Berlin I., 1953, HEDGEHOG FOX ESSAY T

[4] Origin of the Lamina Propria Dendritic Cell Network [J].

Bogunovic, Milena ;

Ginhoux, Florent ;

Helft, Julie ;

Shang, Limin ;

Hashimoto, Daigo ;

Greter, Melanie ;

Liu, Kang ;

Jakubzick, Claudia ;

Ingersoll, Molly A. ;

Leboeuf, Marylene ;

Stanley, E. Richard ;

Nussenzweig, Michel ;

Lira, Sergio A. ;

Randolph, Gwendalyn J. ;

Merad, Miriam .

IMMUNITY, 2009, 31 (03) :513-525

[5] In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination [J].

Bonifaz, LC ;

Bonnyay, DP ;

Charalambous, A ;

Darguste, DI ;

Fujii, SI ;

Soares, H ;

Brimnes, MK ;

Moltedo, B ;

Moran, TM ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (06) :815-824

[6] The biology of intestinal immunoglobulin A responses [J].

Cerutti, Andrea ;

Rescigno, Maria .

IMMUNITY, 2008, 28 (06) :740-750

[7] Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement [J].

Chieppa, Marcello ;

Rescigno, Maria ;

Huang, Alex Y. C. ;

Germain, Ronald N. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (13) :2841-2852

[8] Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network [J].

Chorro, Laurent ;

Sarde, Aurelien ;

Li, Mei ;

Woollard, Kevin J. ;

Chambon, Pierre ;

Malissen, Bernard ;

Kissenpfennig, Adrien ;

Barbaroux, Jean-Baptiste ;

Groves, Richard ;

Geissmann, Frederic .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (13) :3089-3100

[9] Dendritic cells in intestinal immune regulation [J].

Coombes, Janine L. ;

Powrie, Fiona .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :435-446

[10] Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses [J].

Denning, Timothy L. ;

Wang, Yi-Chong ;

Patel, Seema R. ;

Williams, Ifor R. ;

Pulendran, Bali .

NATURE IMMUNOLOGY, 2007, 8 (10) :1086-1094

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