A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides

被引：70

作者：

Sy, LK

Brown, GD

Haynes, R

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Peoples R China

来源：

TETRAHEDRON | 1998年 / 54卷 / 17期

关键词：

D O I：

10.1016/S0040-4020(98)00148-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seven novel cadinane sesquiterpenes, including the seven-membered endoperoxide lactone arteannuin H (1), two six-membered lactones arteannuins 1(4) and J (5), three five-membered lactones arteannuins K-M (6-8) and a keto acid arteannuin N (9) have been isolated from the dried leaves of Artemisia annua in addition to the known compounds dihydroartemisinic acid (27), dihydroarteannuin B (24) and dihydro-epi-deoxyarteannuin B (22). It is proposed that these novel sesquiterpenes are biogenetically related to dihydroartemisinic acid via intermediate secondary and tertiary allylic hydroperoxides. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：4345 / 4356

页数：12

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