Evolution of RNA virus in spatially structured heterogeneous environments

被引:34
作者
Cuevas, JM
Moya, A
Elena, SF
机构
[1] Univ Valencia, Inst Cavanilles Biodivers & Biol Evolut, Valencia, Spain
[2] Univ Valencia, Dept Genet, Valencia, Spain
关键词
changing environments; generalists; host range; migration; specialists; vesicular stomatitis virus; viral evolution;
D O I
10.1046/j.1420-9101.2003.00547.x
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
A hallmark of the infectious cycle for many RNA viruses parasitizing multicellular hosts is the need to invade and successfully replicate in tissues that comprise a variety of cell types. Thus, multicellular hosts represent a heterogeneous environment to evolving viral populations. To understand viral adaptation to multicellular hosts, we took a double approach. First, we developed a mathematical model that served to make predictions concerning the dynamics of viral populations evolving in heterogeneous environments. Second, the predictions were tested by evolving vesicular stomatitis virus in vitro on a spatially structured environment formed by three different cell types. In the absence of gene flow, adaptation was tissue-specific, but fitness in all tissues decreased with migration rate. The performance in a given tissue was negatively correlated with its distance to the tissue hosting the population. This correlation decreased with migration rate.
引用
收藏
页码:456 / 466
页数:11
相关论文
共 38 条
[1]  
Adams R.L.P., 1990, CELL CULTURE BIOCH
[2]   Experimental evolution in Chlamydomonas .1. Short-term selection in uniform and diverse environments [J].
Bell, GAC .
HEREDITY, 1997, 78 :490-497
[3]   EVOLUTION IN HETEROGENEOUS ENVIRONMENTS - EFFECTS OF MIGRATION ON HABITAT SPECIALIZATION [J].
BROWN, JS ;
PAVLOVIC, NB .
EVOLUTIONARY ECOLOGY, 1992, 6 (05) :360-382
[4]  
Bulmer M., 1994, THEORETICAL EVOLUTIO
[5]   Kin selection and parasite evolution: Higher and lower virulence with hard and soft selection [J].
Chao, L ;
Hanley, KA ;
Burch, CL ;
Dahlberg, C ;
Turner, PE .
QUARTERLY REVIEW OF BIOLOGY, 2000, 75 (03) :261-275
[6]  
Cooper LA, 2001, GENETICS, V157, P1403
[7]  
Crill WD, 2000, GENETICS, V154, P27
[8]   Human immunodeficiency virus type 1 populations in blood and semen [J].
Delwart, EL ;
Mullins, JI ;
Gupta, P ;
Learn, GH ;
Holodniy, M ;
Katzenstein, D ;
Walker, BD ;
Singh, MK .
JOURNAL OF VIROLOGY, 1998, 72 (01) :617-623
[9]  
Elena SF, 1999, J EVOLUTION BIOL, V12, P1078, DOI 10.1046/j.1420-9101.1999.00110.x
[10]   Genetic drift and within-host metapopulation dynamics of HIV-1 infection [J].
Frost, SDW ;
Dumaurier, MJ ;
Wain-Hobson, S ;
Brown, AJL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6975-6980