Prospective immunogenicity study of multiple intradermal injections of rabies vaccine in an effort to obtain an early immune response without the use of immunoglobulin

被引：34

作者：

Khawplod, P ^{[1
]}

Wilde, H ^{[1
]}

Tepsumethanon, S ^{[1
]}

Limusanno, S ^{[1
]}

Tantawichien, T ^{[1
]}

Chomchey, P ^{[1
]}

Ayuthaya, ABN ^{[1
]}

Wangroonsarb, Y ^{[1
]}

机构：

[1] Thai Red Cross Soc, Queen Saovabha Mem Inst, World Hlth Org Collaborating Ctr Res Rabies, Bangkok 10330, Thailand

来源：

CLINICAL INFECTIOUS DISEASES | 2002年 / 35卷 / 12期

关键词：

D O I：

10.1086/344954

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study sought to determine whether increasing and accelerating rabies vaccine administration would result in earlier protective levels of neutralizing antibody. Results indicated that the 8- site and double- dose Thai Red Cross intradermal regimens produced higher antibody titers by day 14 but not significantly higher titers by days 5 and 7. Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment.

引用

页码：1562 / 1565

页数：4

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