Interactions of viruses with the cellular DNA repair machinery

被引：82

作者：

Weitzman, MD ^{[1
]}

Carson, CT ^{[1
]}

Schwartz, RA ^{[1
]}

Lilley, CE ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

adenovirus; MRN complex; DNA damage response; parvovirus;

D O I：

10.1016/j.dnarep.2004.03.018

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian cells are equipped with complex machinery to monitor and repair damaged DNA. In addition to responding to breaks in cellular DNA, recent studies have revealed that the DNA repair machinery also recognizes viral genetic material. We review some examples that highliglit the different strategies that viruses have developed to interact with the host DNA repair apparatus. While adenovirus (Ad) inactivates the host machinery to prevent signaling and concaternerization of the vital genome, other viruses may utilize DNA repair to their own advantage. Viral interactions with the repair machinery can also have detrimental consequences for the host cells and their ability to maintain the integrity of the host genome. Exploring the interactions between viruses and the host DNA repair machinery has revealed novel host responses to virus infections and has provided new tools to study the DNA damage response. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1165 / 1173

页数：9

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