Immunogenicity, reactogenicity and safety of two-dose versus three-dose (standard care) hepatitis B immunisation of healthy adolescents aged 11-15 years: A randomised controlled trial

This trial assessed the immunogenicity, safety and reactogenicity of a two-dose hepatitis B immunisation regimen (thiomersal-free Engerix-B (TM) 20 mu g HBsAg doses 6 months apart) compared to the standard three-dose vaccination regimen (preservative-free Engerix-B (TM) 10 mu g HBsAg doses, 0, 1, 6 month dose schedule) in healthy adolescents aged 11-15 years. Subjects were randomly assigned (2:1 ratio) to one of the two regimens (258 to the two-dose [20 mu g] and 126 to the three-dose [10 mu g] regimen) (Study ID 103860/280). One month after the final vaccine dose, the seroprotection (anti-HBs >= 10 mIU/ml) rate in the two-dose (20 mu g) group (233/241 individuals -96.7% seroprotected) was non-inferior to the seroprotection rate in the three-dose (10 mu g) group (111/113 individuals -98.2% seroprotected). Both regimens were shown to be safe and well tolerated. Two doses of Engerix-B (TM) (20 mu g HBsAg) could be considered as an alternative to standard three-dose Engerix-B (TM) (10 mu g HBsAg) immunisation for adolescents aged 11-15 years. (c) 2007 Elsevier Ltd. All rights reserved.