Omeprazole in infants with cimetidine-resistant peptic esophagitis

被引：33

作者：

Alliët, P ^{[1
]}

Raes, M ^{[1
]}

Bruneel, E ^{[1
]}

Gillis, P ^{[1
]}

机构：

[1] Virga Jesse Hosp, Dept Pediat, B-3500 Hasselt, Belgium

来源：

JOURNAL OF PEDIATRICS | 1998年 / 132卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(98)70460-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Twelve neurologically normal infants (age 2.9 +/- 0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cis-apride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.

引用

页码：352 / 354

页数：3

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