Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats

被引：111

作者：

Liu, Chao

Wu, Jiliang

Gu, Jun

Xiong, Zhe

Wang, Fang

Wang, Jianzhi

Wanu, Wei

Chen, Jianguo

机构：

[1] Huazhong Univ Sci & Technol, Dept Pharmacol, Tongji Med Coll, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Dept Neurol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China

[3] Hubei Prov Key Lab Neural Dis, Wuhan 430030, Peoples R China

[4] Xianning Univ, Pharmaceut Coll, Dept Pharmacol, Xianning 437100, Peoples R China

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2007年 / 86卷 / 03期

基金：

中国国家自然科学基金;

关键词：

baicalein; learning; memory; free radical; vascular dementia; SUPEROXIDE-DISMUTASE; VASCULAR DEMENTIA; OXIDATIVE STRESS; SCUTELLARIA-BAICALENSIS; ISCHEMIA-REPERFUSION; ALZHEIMERS-DISEASE; LIPID-PEROXIDATION; MEMORY DYSFUNCTION; GLOBAL-ISCHEMIA; BLOOD-FLOW;

D O I：

10.1016/j.pbb.2006.11.005

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The aim of this study is to investigate the effects of baicalein on cognitive impairment and neuronal degeneration in a rat model of chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). It was found that baicalein (2 or 4 mg/kg/day, i.p.) significantly improved 2VO-induced cognitive deficits and neuropathological changes. Biochemical and histological examinations revealed that baicalein reduced the increased activities of superoxide dismutase (SOD) and malondialdehyde (MDA), and attenuated the decreased activities of glutathione peroxidase (GPx) and catalase in 2VO rats. The results of the present observation suggest that baicalein has therapeutic potential for the treatment of vascular dementia, which is most likely related, at least in part, to its antioxidant action. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：423 / 430

页数：8

共 54 条

[1] The effect of ethanol on lipid peroxidation and glutathione level in the brain stem of rat [J].