Increased frequency of dentate granule cells with basal dendrites in the hippocampal formation of schizophrenics

被引:39
作者
Lauer, M [1 ]
Beckmann, H [1 ]
Senitz, D [1 ]
机构
[1] Univ Wurzburg, Dept Psychiat & Psychotherapy, Neurobiol Lab, D-97080 Wurzburg, Germany
关键词
entorhinal cortex; hippocampus; dentate gyrus; prenatal maldevelopement; migration disorder; neuroplasticity; adult neurogenesis;
D O I
10.1016/S0925-4927(02)00122-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the hippocampal formation of schizophrenics, the detailed morphology of Golgi-impregnated granule cells was examined. These granule cells of the dentate gyrus are interposed between the rostral entorhinal cortex and the hippocampus proper. In these limbic regions significant cytoarchitectural alterations in schizophrenics are reported, giving rise to the concept of a prenatal limbic maldevelopement in schizophrenia. Compared to controls, the frequency of dentate granule cells with basal dendrites was significantly increased in schizophrenics [43% (+/- 3)] vs. [22% (+/- 2) in the control group]. In epilepsy; dentate. granule cells of epileptic patients also develop basal dendrites, which is explained as an adaptive process of plasticity. Similarly, the hippocampal alterations described in schizophrenics could be the sequela of primary entorhinal cytoarchitectural alterations. Since the increase in basal dendrites seems to reflect a process of continuous plasticity, suggesting an increased rate of postnatal granule cell generation, the synthesis of a prenatal limbic maldevelopement with an ongoing process of plasticity might, therefore, supersede the hypothesis of a neurodegeneration in schizophrenia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:89 / 97
页数:9
相关论文
共 52 条
[1]  
AKBARIAN S, 1993, ARCH GEN PSYCHIAT, V50, P169
[2]  
Akil M, 1997, AM J PSYCHIAT, V154, P1010
[3]   Decreased density of tyrosine hydroxylase-immunoreactive axons in the entorhinal cortex of schizophrenic subjects [J].
Akil, M ;
Edger, CL ;
Pierri, JN ;
Casali, S ;
Lewis, DA .
BIOLOGICAL PSYCHIATRY, 2000, 47 (05) :361-370
[4]   PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].
ALEXANDER, GE ;
DELONG, MR ;
STRICK, PL .
ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381
[5]   Further evidence of abnormal cytoarchitecture of the entorhinal cortex in schizophrenia using spatial point pattern analyses [J].
Arnold, SE ;
Ruscheinsky, DD ;
Han, LY .
BIOLOGICAL PSYCHIATRY, 1997, 42 (08) :639-647
[6]   Recent advances in defining the neuropathology of schizophrenia [J].
Arnold, SE ;
Trojanowski, JQ .
ACTA NEUROPATHOLOGICA, 1996, 92 (03) :217-231
[7]  
ARNOLD SE, 1991, ARCH GEN PSYCHIAT, V48, P625
[8]  
Arnold SE, 2000, ANN NY ACAD SCI, V911, P275
[9]   PRENATAL DISTURBANCES OF NERVE-CELL MIGRATION IN THE ENTORHINAL REGION - A COMMON VULNERABILITY FACTOR IN FUNCTIONAL PSYCHOSES [J].
BECKMANN, H ;
JAKOB, H .
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1991, 84 (1-2) :155-164
[10]  
BECKMANN H, 2001, CONT PSYCHIAT, V3, P81