Genetically engineered mice have been generated to model a variety of neurological disorders. Several of these models have provided valuable insights into the pathogenesis of the relevant diseases; however, they have rarely reproduced all, or even most, of the features observed in the corresponding human conditions. Here, we review the challenges that must be faced when attempting to accurately reproduce human brain disorders in mice, and discuss some of the ways to overcome them. Building on the knowledge gathered from the study of existing mutants, and on recent progress in phenotyping mutant mice, we anticipate better methods for preclinical interventional trials and significant advances in the understanding and treatment of neurological diseases.
机构:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USA
Bolivar, V
;
Cook, M
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机构:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USA
Cook, M
;
Flaherty, L
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机构:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USA
机构:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USA
Bolivar, V
;
Cook, M
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USA
Cook, M
;
Flaherty, L
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr Labs & Res, Lab Dev Genet, Mol Genet Program, Albany, NY 12201 USA