Modelling brain diseases in mice: The challenges of design and analysis

被引:64
作者
Watase, K
Zoghbi, HY
机构
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[2] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
关键词
D O I
10.1038/nrg1045
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Genetically engineered mice have been generated to model a variety of neurological disorders. Several of these models have provided valuable insights into the pathogenesis of the relevant diseases; however, they have rarely reproduced all, or even most, of the features observed in the corresponding human conditions. Here, we review the challenges that must be faced when attempting to accurately reproduce human brain disorders in mice, and discuss some of the ways to overcome them. Building on the knowledge gathered from the study of existing mutants, and on recent progress in phenotyping mutant mice, we anticipate better methods for preclinical interventional trials and significant advances in the understanding and treatment of neurological diseases.
引用
收藏
页码:296 / 307
页数:12
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