Randomly ordered addressable high-density optical sensor arrays

被引：241

作者：

Michael, KL ^{[1
]}

Taylor, LC ^{[1
]}

Schultz, SL ^{[1
]}

Walt, DR ^{[1
]}

机构：

[1] Tufts Univ, Dept Chem, Max Tishler Lab Organ Chem, Medford, MA 02155 USA

来源：

ANALYTICAL CHEMISTRY | 1998年 / 70卷 / 07期

关键词：

D O I：

10.1021/ac971343r

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Array-based sensors provide an architecture for multianalyte sensing. In this paper, we report a new approach for array fabrication. Sensors are made by immobilizing different reactive chemistries on the surfaces of microspheres. Sensor arrays are prepared by randomly distributing a mixture of microsphere sensors on an optical substrate containing thousands of micrometer-scale wells. The sensors occupy a different location from array to array; thus the identity of each sensor is ascertained and registered on the detector using encoding schemes, rather than by a predetermined location in the array. The approach thereby shifts the demand from fabrication to signal processing. The availability of commercial image analysis software makes such a shift both cost-effective and time efficient.

引用

页码：1242 / 1248

页数：7

共 34 条

[1]

Amatore C., 1995, PHYS ELECTROCHEMISTR, P131

[2] New developments in particle-based immunoassays: Introduction [J].

Bangs, LB .

PURE AND APPLIED CHEMISTRY, 1996, 68 (10) :1873-1879

[3]

BANGS LB, 1996, LIQUID SURFACE BORNE, P687

[4] COMBINED IMAGING AND CHEMICAL SENSING USING A SINGLE OPTICAL IMAGING FIBER [J].

BRONK, KS ;

MICHAEL, KL ;

PANTANO, P ;

WALT, DR .

ANALYTICAL CHEMISTRY, 1995, 67 (17) :2750-2757

[5] Intrinsic sol-gel clad fiber-optic sensors with time-resolved detection [J].

Browne, CA ;

Tarrant, DH ;

Olteanu, MS ;

Mullens, JW ;

Chronister, EL .

ANALYTICAL CHEMISTRY, 1996, 68 (14) :2289-2295

[6] All-solid state miniaturized fluorescence sensor array for the determination of critical gases and electrolytes in blood [J].

Bruno, AE ;

Barnard, S ;

Rouilly, M ;

Waldner, A ;

Berger, J ;

Ehrat, M .

ANALYTICAL CHEMISTRY, 1997, 69 (03) :507-513

[7]

CARNEY J, 1990, Analytical Proceedings, V27, P99

[8] Accessing genetic information with high-density DNA arrays [J].

Chee, M ;

Yang, R ;

Hubbell, E ;

Berno, A ;

Huang, XC ;

Stern, D ;

Winkler, J ;

Lockhart, DJ ;

Morris, MS ;

Fodor, SPA .

SCIENCE, 1996, 274 (5287) :610-614

[9] Behaviour of surface acoustic wave interdigitated array electrode sensor in non-aqueous solution and determination of blood plasma recalcification time [J].

Chen, K ;

Liu, DZ ;

Nie, LH ;

Yao, SZ .

BIOSENSORS & BIOELECTRONICS, 1996, 11 (05) :515-521

[10]

CHIGUSA Y, 1986, OPTOELECTRON DEVICES, V1, P203

← 1 2 3 4 →