Azithromycin retards Pseudomonas aeruginosa Biofilm Formation

被引：115

作者：

Gillis, RJ ^{[1
]}

Iglewski, BH ^{[1
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2004年 / 42卷 / 12期

关键词：

D O I：

10.1128/JCM.42.12.5842-5845.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a How cell biofilm model, we showed that a sub-MIC of azithromycin (AZM) can delay but not inhibit Pseudomonas aeruginosa biofilm formation and results in the development of a stable AZM resistance phenotype. Furthermore, mature biofilms were not affected by AZM.

引用

页码：5842 / 5845

页数：4

共 21 条

[1] Cystic fibrosis [J].

Brennan, AL ;

Geddes, DM .

CURRENT OPINION IN INFECTIOUS DISEASES, 2002, 15 (02) :175-182

[2] A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms [J].

Brooun, A ;

Liu, SH ;

Lewis, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (03) :640-646

[3] Effect of subinhibitory concentrations of azithromycin on adherence of Pseudomonas aeruginosa to bronchial mucins collected from cystic fibrosis patients [J].

Carfartan, G ;

Gerardin, P ;

Turck, D ;

Husson, MO .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (04) :686-688

[4] Quorum-sensing genes in Pseudomonas aeruginosa biofilms:: Their role and expression patterns [J].

De Kievit, TR ;

Gillis, R ;

Marx, S ;

Brown, C ;

Iglewski, BH .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (04) :1865-1873

[5] Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial [J].

Equi, A ;

Balfour-Lynn, IM ;

Bush, A ;

Rosenthal, M .

LANCET, 2002, 360 (9338) :978-984

[6] Biofilm formation by Pseudomonas aeruginosa:: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin [J].

Favre-Bonté, S ;

Köhler, T ;

Van Delden, C .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) :598-604

[7] PHARMACOKINETIC AND INVIVO STUDIES WITH AZITHROMYCIN (CP-62,993), A NEW MACROLIDE WITH AN EXTENDED HALF-LIFE AND EXCELLENT TISSUE DISTRIBUTION [J].

GIRARD, AE ;

GIRARD, D ;

ENGLISH, AR ;

GOOTZ, TD ;

CIMOCHOWSKI, CR ;

FAIELLA, JA ;

HASKELL, SL ;

RETSEMA, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (12) :1948-1954

[8] Quantification of biofilm structures by the novel computer program COMSTAT [J].

Heydorn, A ;

Nielsen, AT ;

Hentzer, M ;

Sternberg, C ;

Givskov, M ;

Ersboll, BK ;

Molin, S .

MICROBIOLOGY-SGM, 2000, 146 :2395-2407

[9] Experimental reproducibility in flow-chamber biofilms [J].

Heydorn, A ;

Ersboll, BK ;

Hentzer, M ;

Parsek, MR ;

Givskov, M ;

Molin, S .

MICROBIOLOGY-UK, 2000, 146 :2409-2415

[10] Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth [J].

Hoiby, N ;

Johansen, HK ;

Moser, C ;

Song, ZJ ;

Ciofu, O ;

Kharazmi, A .

MICROBES AND INFECTION, 2001, 3 (01) :23-35

← 1 2 3 →