DNA Analysis by Dynamic Chemistry

被引：48

作者：

Bowler, Frank R. ^{[1
]}

Diaz-Mochon, Juan J. ^{[1
]}

Swift, Michael D. ^{[1
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

DNA analysis; dynamic chemistry; genotyping; peptide nucleic acids; single-nucleotide polymorphisms; TEMPLATE-DIRECTED SYNTHESIS; PEPTIDE NUCLEIC-ACIDS; RECOGNITION; LIGATION; REACTIVITY; MUTATIONS; STACKING; ANALOGS; ARRAYS; RNA;

D O I：

10.1002/anie.200905699

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Finding flaws: An enzyme-free method of DNA analysis raises the possibility of analyzing slngle-nucleotlde polymorphism, indel, and abaslc sites using mass spectrometry as a readout tool. The methodology Is suitable for the dual analysis of heterozygous samples. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：1809 / 1812

页数：4

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