Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome

被引：388

作者：

Fernandez, Fabian ^{[1
]}

Morishita, Wade ^{[1
]}

Zuniga, Elizabeth ^{[1
]}

Nguyen, James ^{[1
]}

Blank, Martina ^{[1
]}

Malenka, Robert C. ^{[1
]}

Garner, Craig C. ^{[1
]}

机构：

[1] Stanford Univ, Nancy Pritzker Lab, Dept Psychiat & Behav Sci, Palo Alto, CA 94305 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/nn1860

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a condition that could compromise synaptic plasticity and mnemonic processing. We show that chronic systemic treatment of these mice with GABA(A) antagonists at non-epileptic doses causes a persistent post-drug recovery of cognition and long-term potentiation. These results suggest that over-inhibition contributes to intellectual disabilities associated with Down syndrome and that GABA(A) antagonists may be useful therapeutic agents for this disorder.

引用

页码：411 / 413

页数：3

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