Estrogen can protect neurons: modes of action

被引：75

作者：

Behl, C ^{[1
]}

机构：

[1] MPI Psychiat, D-80804 Munich, Germany

[2] Univ Mainz, Inst Physiol Chem & Pathobiochem, D-55099 Mainz, Germany

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2002年 / 83卷 / 1-5期

关键词：

estrogen receptor; 17; beta-estradiol; reactive oxygen species;

D O I：

10.1016/S0960-0760(02)00271-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The female sex hormone estrogen is a steroid that activates estrogen receptors which may act as nuclear transcription factors. In addition to its well-known functions in reproductive tissue, estrogen and its receptors may also act in various regions throughout the body including the brain. Recently, the neuroprotective functions of estrogen have been investigated in greater detail. Besides acting as a powerful neuroprotective antioxidant molecule estrogen may activate the transcription of neuroprotective genes directly and may cross-talk with various intracellular signaling processes. The various modes of action of estrogen via receptor activation and in a non-receptor fashion are currently under intensive investigation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：195 / 197

页数：3

共 11 条

[1] Oestrogen as a neuroprotective hormone [J].