Consequences of regulated pre-mRNA splicing in the immune system

被引：208

作者：

Lynch, KW ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 12期

关键词：

D O I：

10.1038/nri1497

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alternative splicing is widely recognized to be a ubiquitous and crucial mechanism for generating protein diversity and regulating protein expression. Numerous immunologically relevant genes have been found to undergo alternative splicing; however, there has been little effort to develop a coherent picture of how alternative splicing might be used as a general mechanism to regulate the function of the immune system. In this review, I summarize the mechanisms by which splicing is controlled in T cells, and discuss the role of alternative splicing and alternative isoform expression in the regulation of T-cell activation and function.

引用

页码：931 / 940

页数：10

共 90 条

[1] Generation of a variant of human interleukin-4 by alternative splicing [J].

Alms, WJ ;

Atamas, SP ;

Yurovsky, VV ;

White, B .

MOLECULAR IMMUNOLOGY, 1996, 33 (4-5) :361-370

[2] PARTICIPATION IN NORMAL IMMUNE-RESPONSES OF A METASTASIS-INDUCING SPLICE VARIANT OF CD44 [J].

ARCH, R ;

WIRTH, K ;

HOFMANN, M ;

PONTA, H ;

MATZKU, S ;

HERRLICH, P ;

ZOLLER, M .

SCIENCE, 1992, 257 (5070) :682-685

[3]

ASTIER A, 1994, J IMMUNOL, V152, P201

[4] Alternative splice variants of cytokines: Making a list [J].

Atamas, SP .

LIFE SCIENCES, 1997, 61 (12) :1105-1112

[5] Splice variant in TCRζ links T cell receptor signaling to a G-protein-related signaling pathway [J].

Atkinson, TP ;

Hall, CG ;

Goldsmith, J ;

Kirkham, PM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 310 (03) :761-766

[6]

BARTOLAZZI A, 1995, J CELL SCI, V108, P1723

[7] Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Rα [J].

Benbernou, N ;

Muegge, K ;

Durum, SK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (10) :7060-7065

[8] EXON RECOGNITION IN VERTEBRATE SPLICING [J].

BERGET, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2411-2414

[9] Identification of a novel IL-6 isoform binding to the endogenous IL-6 receptor [J].

Bihl, MP ;

Heinimann, K ;

Rüdiger, JJ ;

Eickelberg, O ;

Perruchould, AP ;

Tamm, M ;

Roth, M .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 27 (01) :48-56

[10]

Black D L, 2003, Prog Mol Subcell Biol, V31, P187

← 1 2 3 4 5 6 7 8 9 →