Effect of taurine on toxicity of copper in rats

被引：63

作者：

Hwang, DF ^{[1
]}

Wang, LC ^{[1
]}

Cheng, HM ^{[1
]}

机构：

[1] Natl Taiwan Ocean Univ, Dept Marine Food Sci, Keelung, Taiwan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1998年 / 36卷 / 03期

关键词：

D O I：

10.1016/S0278-6915(97)00146-4

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

An attempt was made to study the effect of taurine on the toxicity of copper in male Wistar rats. The rats were divided into eight groups and fed different diets with or without supplement of 5% taurine and 150-600 ppm copper for 2 months. It was found that the levels of copper and malondialdehyde (MDA) in the liver, and the activities of aspartate transaminase (AST) and alanine transaminase (ALT) in the plasma of rats were increased with the increasing dose of copper. However, the levels of copper and MDA, and the enzyme activities of AST and ALT in the rats fed with supplement of taurine were significantly lower than in the rats fed without supplement of taurine. The level of copper in the faeces of rats treated with taurine and copper was higher than that of rats treated with copper alone. It indicated that taurine might play a role in reducing the toxic effect of copper in rats. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：239 / 244

页数：6

共 20 条

[1]

EVENSON MA, 1975, CLIN CHEM, V21, P619

[2]

HAMAGUCHI T, 1988, RES COMMUN CHEM PATH, V59, P21

[3]

HAYWOOD S, 1985, J PATHOL, V145, P149, DOI 10.1002/path.1711450203

[4]

Horwitz W, 1984, OFFICIAL METHODS ANA, P871

[5]

HUNG TC, 1988, HAZARDOUS WASTE DETE, P869

[6]

HUNG TC, 1989, ACTA OCEANOGR TAIWAN, V23, P33

[7]

HUNG TC, 1991, ENV PROTECTION COAST, P221

[8] BIOCHEMISTRY AND PHYSIOLOGY OF TAURINE AND TAURINE DERIVATIVES [J].

JACOBSEN, JG ;

SMITH, LH .

PHYSIOLOGICAL REVIEWS, 1968, 48 (02) :424-+

[9]

Konosu S., 1982, In 'Chemistry & biochemistry of marine food products' G[see FSTA (1983) 15 G7R466]., P367

[10]

Puri S. C., 1980, APPL STAT FOOD AGR S, P146

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