Tacrolimus in corticosteroid-resistant ulcerative colitis

被引：31

作者：

Matsuhashi, N ^{[1
]}

Nakajima, A ^{[1
]}

Watanabe, K ^{[1
]}

Komeno, Y ^{[1
]}

Suzuki, A ^{[1
]}

Ohnishi, S ^{[1
]}

Omata, M ^{[1
]}

Kondo, K ^{[1
]}

Usui, Y ^{[1
]}

Iwadare, J ^{[1
]}

Watanabe, T ^{[1
]}

Nagawa, H ^{[1
]}

Muto, T ^{[1
]}

机构：

[1] Univ Tokyo, Fac Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2000年 / 35卷 / 08期

关键词：

ulcerative colitis; tacrolimus; cyclosporine A; immunosuppressant; Crohn's disease;

D O I：

10.1007/s005350070065

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report a case of refractory ulcerative colitis treated with tacrolimus. The patient was a 73-year-old woman with a 45-year history of ulcerative colitis. An attack unresponsive to intravenous corticosteroid therapy occurred when she was age 73. Leukocytapheresis therapy was attempted, but was discontinued because of the patient's poor general condition. Cyclosporine A therapy brought about fair control of the disease. A liver injury that was suspected to be associated with this agent, however, occurred within 5 weeks of its initiation. At that time, the cyclosporine A was discontinued and azathioprine treatment was started. Within 6 weeks, signs of exacerbation of the ulcerative colitis became apparent. Tacrolimus administered at that time brought about remission of the disease, and the corticosteroid dose was then reduced. Tacrolimus, like cyclosporine A, appears to be effective for the treatment of attacks of ulcerative colitis.

引用

页码：635 / 640

页数：6

共 22 条

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Tacrolimus (FK-506) treatment of fulminant colitis in a child [J].