The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite

被引:89
作者
Rogers, MJ [1 ]
Cundliffe, E [1 ]
McCutchan, TF [1 ]
机构
[1] NIAID, Growth & Dev Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1128/AAC.42.3.715
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The antibiotic microfoccin is a potent growth inhibitor of the human malaria parasite Plasmodium falciparum, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding levels of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.
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页码:715 / 716
页数:2
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