Fluorescence in situ hybridization characterization of different cryptic BCR-ABL rearrangements in chronic myeloid leukemia

被引：21

作者：

Haigh, S ^{[1
]}

Cuthbert, G ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

CANCER GENETICS AND CYTOGENETICS | 2004年 / 155卷 / 02期

关键词：

D O I：

10.1016/j.cancergencyto.2004.02.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using fluorescence in situ hybridization probes, obtained from bacterial artificial chromosome (BAC) libraries that relate to sequences either side of the BCR and ABL genes, this study characterized four chronic myeloid leukemia cases with cryptic BCR-ABL rearrangements. Each case showed evidence of a different underlying mechanism: one case showed a microinsertion of BCR into ABL, another a microinsertion of ABL into BCR, and the third showed a complex rearrangement. including deletion of adjacent flanking sequences, consistent with the reverse translocation model of cryptic rearrangement. The fourth case also showed evidence of a more complex rearrangement involving chromosome 1. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：132 / 137

页数：6

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