Instrumentation for combinatorial and high-throughput polymer research: A short overview

被引:51
作者
Schmatloch, S
Meier, MAR
Schubert, US
机构
[1] Eindhoven Univ Technol, Lab Macromol Chem & Nanosci, NL-5600 MB Eindhoven, Netherlands
[2] Dutch Polymer Inst, NL-5600 MB Eindhoven, Netherlands
关键词
automated synthesis; combinatorial materials research; high-throughput screening; instrumentation; polymers; robots;
D O I
10.1002/marc.200390018
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Starting in biochemistry and pharmaceutical chemistry, combinational methods, automated systhesis and high-throughput characterization are being further developed for organic systhesis and polymer research. The development is strongly driven by the achievements in biochemistry and pharmaceutical chemistry and the need to minimize the time-to-market for novel polymeric products. The success of high-throughput methodologies in polymer science is partially limited by the commercially available hardware (synthesizers, workstations, robots, online-characterization instruments, etc.) and software. A short overview of commercially available equipment for polymer research is provided in this Review.
引用
收藏
页码:33 / 46
页数:14
相关论文
共 16 条
[1]   A versatile and cost-effective approach to automated laboratory organic synthesis [J].
Armitage, MA ;
Smith, GE ;
Veal, KT .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 1999, 3 (03) :189-195
[2]  
BAUSER M, 2002, HDB COMBINATORIAL CH
[3]  
BRUMMER H, 1999, GIT LABORFACHZEITSCH, V43, P598
[4]   THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].
BUNIN, BA ;
PLUNKETT, MJ ;
ELLMAN, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712
[5]   Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules [J].
Cheng, S ;
Comer, DD ;
Williams, JP ;
Myers, PL ;
Boger, DL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (11) :2567-2573
[6]   USE OF PEPTIDE-SYNTHESIS TO PROBE VIRAL-ANTIGENS FOR EPITOPES TO A RESOLUTION OF A SINGLE AMINO-ACID [J].
GEYSEN, HM ;
MELOEN, RH ;
BARTELING, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13) :3998-4002
[7]   Breaking the new bottleneck: Automated synthesis in chemical process research and development [J].
Harre, M ;
Tilstam, U ;
Weinmann, H .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 1999, 3 (05) :304-318
[8]  
Hiebl J, 2000, CHIM OGGI, V18, P41
[9]  
HOOGENBOOM R, 2002, POLYM PREPR AM CHEM, V43, P969
[10]  
MAIN BG, ISLAR 93 P