Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency

被引：46

作者：

Kaplan, M

Rubaltelli, FF

Hammerman, C

Vilei, MT

Leiter, C

Abramov, A

Muraca, M

机构：

[1] HEBREW UNIV JERUSALEM, DEPT PEDIAT, SHAARE ZEDEK MED CTR, SCH MED, IL-91031 JERUSALEM, ISRAEL

[2] HEBREW UNIV JERUSALEM, CLIN HEMATOL LAB, SHAARE ZEDEK MED CTR, SCH MED, IL-91031 JERUSALEM, ISRAEL

[3] UNIV FLORENCE, DIV NEONATOL, FLORENCE, ITALY

[4] UNIV PADUA, DEPT INTERNAL MED, I-35100 PADUA, ITALY

来源：

JOURNAL OF PEDIATRICS | 1996年 / 128卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(96)80138-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We used a system capable of measuring conjugated bilirubin and its monoconjugated and diconjugated fractions in serum to assess bilirubin conjugation in 29 glucose-6-phosphate dehydrogenase (G6PD)-deficient, term, male newborn infants and 35 control subjects; all had serum bilirubin levels greater than or equal to 256 mu mol/L(15 mg/dl), The median value for diconjugated bilirubin was lower in the G6PD-deficient neonates than in control subjects (0.06 (range 0.00 to 1.84) vs 0.21 (range 0.00 to 1.02) mu mol/L, p = 0.006), Diglucuronide was undetectable in 11 (38.9%) of the G6PD-deficient infants versus 3 (8.6%) of the control subjects (p = 0.015), These findings imply a partial defect of bilirubin conjugation not previously demonstrated in G6PD-deficient newborn infants.

引用

页码：695 / 697

页数：3

共 16 条

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